CAR-T Cell Therapy

Content:

1. Indications for CAR-T Cell Therapy
2. Steps of CAR-T Therapy Treatment
3. What Results Can Be Achieved
4. Possible Side Effects
5. Why Patients Choose Our Center
6. Treatment Cost

CAR-T cell therapy is one of the most promising directions in the treatment of hematologic malignancies and autoimmune diseases — an innovative gene and cell therapy method that targets and destroys malignant cells.

CAR-T cell (chimeric antigen receptor T-cell) therapy is a modern, highly precise treatment approach based on modifying a patient’s own immune T-cells. Normally, T-lymphocytes recognize and eliminate foreign elements in the body, but cancer cells can “mask” themselves and avoid immune detection.

The essence of CAR-T therapy is as follows: the patient’s blood is processed through an apheresis device to collect white blood cells. T-lymphocytes are isolated, activated, and genetically modified by introducing a synthetic chimeric antigen receptor (CAR). This receptor enables T-cells to recognize specific tumor antigens and destroy malignant cells with high precision.

After activation and transduction, the cells are expanded in a nutrient medium until the required number is reached and then re-infused into the patient. These “reprogrammed” lymphocytes can fight even relapsed or refractory disease forms.

In Belarus, CAR-T therapy is officially used for treating aggressive B-cell leukemias and lymphomas. Recently, it has also been introduced for multiple myeloma and autoimmune disorders — offering new hope for patients with complex and resistant disease forms.

Indications for CAR-T Cell Therapy and Who can Benefit from This

• Relapsed or refractory multiple myeloma and other plasma cell disorders
• Relapsed/refractory B-cell acute lymphoblastic leukemia
• Relapsed/refractory B-cell lymphomas, including:
  • Diffuse large B-cell lymphoma (DLBCL)
  • Follicular lymphoma
  • Marginal zone lymphoma
  • Mantle cell lymphoma
  • Burkitt’s lymphoma
• Chronic lymphocytic leukemia / small lymphocytic lymphoma
• Refractory autoimmune conditions (systemic lupus erythematosus, systemic sclerosis, multiple sclerosis, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, etc.)

Steps of CAR-T Therapy Treatment

1. Initial Consultation
   A certified CAR-T specialist assesses indications, prescribes additional tests, and sets up a treatment plan.
2. Leukapheresis
   The patient’s white blood cells are collected via an apheresis machine in a 2–4-hour procedure.
3. T-Cell Manufacturing
   In the laboratory, T-cells are genetically modified to express the CAR receptor and expanded to the therapeutic dose.
4. Lymphodepletion
   Prior to infusion, the patient undergoes a short chemotherapy course to improve CAR-T engraftment and persistence.
5. CAR-T Cell Infusion
   The modified cells are infused intravenously in a single short procedure (about 30 minutes).
6. Immune Response Activation
   The infused cells circulate and attack malignant cells, stimulating the immune system.
7. Medical Monitoring
   The patient stays 2–4 weeks in a comfortable single hospital room under 24/7 medical supervision.

What Results Can Be Achieved

• Long-term remission even in aggressive or relapsed hematologic and autoimmune diseases
• Lower toxicity compared with chemotherapy or radiotherapy
• Effective treatment for patients unresponsive to standard methods
• Improved survival and quality of life even in advanced oncological cases

Possible Side Effects and Safety Profile

• Cytokine Release Syndrome (CRS): fever, chills, weakness, tachycardia
• Neurological symptoms: confusion, headache, speech disorders, tremor, encephalopathy, rarely seizures
• Hematologic toxicity: temporary decrease in blood cell counts
• Infectious complications due to immune suppression
• Hypotension or hypoxia during severe CRS
• Allergic reactions to drugs or cell components

Severe reactions are rare and usually well controlled by experienced specialists.

Why Patients Choose Our Center

• Experienced specialists in hematology, immunology, and transplantation
• Multidisciplinary approach – coordinated work of hematologists, immunologists, and others
• Transparency – full explanation of all procedures, risks, and treatment costs
• Cutting-edge technologies for diagnosis, cell processing, and therapy
• Round-the-clock monitoring and comfortable inpatient conditions

Treatment Cost

* When the full CAR-T therapy package is provided, the cost of the initial consultation is included in the total
price.
** If a repeated CAR-T cell production procedure is required, a 15% discount is
granted (excluding the cost of consumables and medical devices).